| 각막윤부줄기세포결핍이 있는 환자에서 동종각막윤부이식술의 장기간 임상 경과 |
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이승현, 오한진, 유인천, 윤경철 |
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Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea |
| Long-term Results of Keratolimbal Allograft Transplantation in Patients with Limbal Stem Cell Deficiency |
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Seung-Hyun Lee, Han-Jin Oh, In-Cheon You, Kyung-Chul Yoon |
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| Abstract |
Purpose
To evaluate the long-term outcome of keratolimbal allograft (KLAL) in patients with ocular surface disease secondary to limbal stem cell deficiency (LSCD). Methods: Eleven eyes of 10 patients with LSCD as defined by impression cytology, who underwent total or partial KLAL and were followed up at least 36 months, were investigated. Survival rate of graft, risk factor for graft failure, and change of visual acuity were analyzed. Results: Eight eyes of 7 patients underwent total KLAL and 3 eyes of 3 patients underwent partial KLAL. The mean period of graft survival was 17.92±13.64 months (range, 1∼45 months). The cumulative survival rate was 64.3% at 1 years, 28.6% at 2 years, and 28.6% at 3 years postoperatively. Graft survival did not correlated with graft extent. There were no significant changes of visual acuity after surgery. Conclusions: In patients with LSCD, KLAL requires the continuous systemic immune suppression. The survival rate of KLAL declines progressively with time. (Korean J Optom Vis Sci 2007;6(1):29-35) |
| Key Words:
Keratolimbal allograft (KLAL), Limbal stem cell deficiency (LSCD) |
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