Annals of Optometry and Contact Lens 2017;16(4):129-135.
Published online December 25, 2017.
Safety and Effectiveness of Selective Retina Therapy: Systematic Review
Jin A Mo, Mi Hye Jeon, RN, You Jin Jung, RN, Min Lee, Ha Kyoung Kim
Department of New Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency1, Seoul, Korea
Department of Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency2, Seoul, Korea
Department of Research Planning & Cooperation Team, National Evidence-based Healthcare Collaborating Agency3, Seoul, Korea
Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine4, Seoul, Korea
Received: 14 December 2017   • Revised: 17 December 2017   • Accepted: 17 December 2017
The safety and effectiveness of Selective Retina Therapy as a procedure that induces the regeneration of the retinal pigment epithelial cells by selectively destroying only the retinal pigment epithelial cell in patients with retinal diseases were assessed. A total of 9 literatures were included in the final assessment by applying the criteria for selection and exclusion. Tools of Scottish Intercollegiate Guidelines Network were used for assessment of the quality of literature, and levels of the basis and rankings of recommendation were selected accordingly to describe the results of the assessment. Safety was assessed by means of manifestation of complications on the basis of a total of 5 literatures. This technology was assessed to have no safety problem. Regarding the thickness of the retina, a key effectiveness variable, reports were made in 3 literatures on the diabetic macular edema, 1 literature on the central serous chorioretinopathy. Regarding the thickness of the retina made report on diabetic macular edema patient in terms of the changes following 6 months of follow-up observation. Although the thickness was reduced from 383 ± 80 μm prior to intervention to 370 ± 82 μm following the intervention, there was no statistically significant difference. It was reported that the thickness was reduced from 232 ± 120 μm prior to intervention to 210 ± 132 μm following the intervention without any report on the statistical values. Although there is no safety problem with the Selective Retina Therapy when implemented on diabetic macular edema, there are inadequate literatures that made report on the key effectiveness variables of the therapy including the changes in the thickness of the retina and regeneration of the retinal pigment epithelial cells, and comparison between the effect of using this technique along and the existing treatments on the extent of the damages to the surrounding tissues, making the assessment of the effectiveness of this technology difficulty. Moreover, it is deemed that there are inadequate researches for determination of its clinical effectiveness since the clinical sites with drug therapy as the fundamental treatment are not reflected.
Key Words: Effectiveness; Retinal pigment epithelial regeneration; Safety; Selective retina therapy
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