| 보툴리눔 독소를 이용한 상윤부각결막염의 치료 |
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전연숙, 김재찬 |
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중앙대학교 의과대학 중앙대학교병원 안과학교실 |
| Treatment of Superior Limbic Keratoconjunctivitis Using Botulinum Toxin A |
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Yeoun Sook Chun, Jae Chan Kim |
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Department of Ophthalmology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea |
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Received: 27 August 2014 • Revised: 17 October 2014 • Accepted: 22 October 2014 |
| Abstract |
Purpose: To evaluate the changes of clinical symptoms and vital stainings before and after injection of botulinum toxin A into Riolan’s muscle in the treatment of patients with superior limbic keratoconjunctivitis (SLK).
Methods: Ten eyes of 5 patients diagnosed with SLK were injected with botulinum toxin A into the pretarsal orbicularis muscle, or Riolan’s muscle. The changes of clinical symptoms and stainings with fluorescein and rose bengal were evaluated on the day of diagnosis and at 1 week, 2 weeks, 4 weeks, and then monthly 6 months after the injection.
Results: The mean age was 46.8 years. Four patients were female and 1 was male. Dry eye syndrome and horizontal conjunctival corrugation were found in all 5 patients, superior conjunctivochalasis in 3 patients, and floppy eye lid syndrome in 1 patient. All five patients showed distinct improvement in clinical symptoms within 1 week after the injection. Improvement of vital stainings was observed at 2 weeks after the injection, and its effect maintained for 4.0 months (2-6 months). There was no ptosis associated with botulinum toxin injection.
Conclusions: Injection of botulinum toxin into Riolan’s muscle, which maintains lid tone, resolved symptoms and signs associated with SLK very effectively and rapidly. |
| Key Words:
Blink related microtrauma, Botulinum toxin A, Riolan muscle, Superior limbic keratoconjunctivitis |
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