| 가토의 각막상피제거 후 미국 식품의약청 기준으로 점안한 목시플로사신과 가티플로사신의 창상 치유 효과 비교 |
|
전은정, 정성근 |
|
Department of Ophthalmology, The Catholic University of Korea College of Medicine, Seoul, Korea |
| Wound Healing of Moxifloxacin and Gatifloxacin by FDA Standards after Corneal Epithelial Removal in Rabbits |
|
Eun-Jung Jun, Sung Kun Chung |
|
|
| Abstract |
Purpose
This study was performed to compare the effect on epithelial healing and penetration into aqueous humor of the fourth-generation fluoroquinolones following corneal epithelial removal. The administered drugs were VigamoxTM and ZymarTM which differentiates each other by its active ingredients or the presence of benzalkonium chloride. Methods: Eighteen eyes of 9 New Zealand white rabbits were randomized to receive VigamoxTM, ZymarTM following anterior keratectomy with 6.0 mm in diameter. Eyes were dosed with each antibiotic according to its Food and Drug Administration (FDA) approval; i.e. VigamoxTM was dosed three times daily for a week, and ZymarTM was dosed every two hours for the first two days and then four times daily for following five days. Beginning on postoperative day 0, photos were taken daily to measure the area of residual epithelial defects. Anterior chamber paracentesis was done to determine drug concentration at postoperative day 1, 2 and 7. Results: Mean healing time for VigamoxTM and ZymarTM was 2.8±0.45 and 3.0±0.71, respectively (p=0.856). No statistically significant differences of the mean healing time and mean area of healed corneal wound were noted among the two groups. A tendency for higher concentration of ZymarTM to that of VigamoxTM was shown for the first postopertive two days but no difference was checked between two groups at postoperative day 7 (p=0.322). Conclusions: Although the two groups differ by the active ingredients or the presence of preservatives, no significant differences were found in the epithelial healing effect or anterior chamber concentration with short-term dosing for 1 week in this trial. (Korean J Optom Vis Sci 2007;6(1):36-42) |
| Key Words:
Corneal wound healing effect, Drug concentration in aqueous chamber, Gatifloxacin, Moxifloxacin |
|
PDF Links
Download Citation
