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Effects of 0.15% Sodium Hyaluronate on Tear Film and Ocular Surface Disorders after Vitrectomy Surgery
Ann Optom Contact Lens 2021;20:22-31
Published online March 25, 2021
© 2021 The Korean Optometry & Contact Lens Study Society

Ji-Ho Choi, MD1, Young-Myoung Park, MD1, Jin-gu Jeong, MD, PhD1,2,3, Nam-Chun Cho, MD, PhD1,2,3, In-Cheon You, MD, PhD1,2,3

Department of Ophthalmology, Jeonbuk National University Medical School1, Jeonju, Korea
Research Institute of Clinical Medicine, Jeonbuk National University2, Jeonju, Korea
Biomedical Research Institute, Jeonbuk National University Hospital3, Jeonju, Korea
Correspondence to: In-Cheon You, MD, PhD
Department of Ophthalmology, Jeonbuk National University Hospital, #20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea
Tel: 82-63-250-2581, Fax: 82-63-250-1959
* This work was supported by a research grant of Taejoon Pharmaceutical. Co., LTD (Grant No. CHU 2018-10-019-001).
Received January 7, 2021; Revised February 5, 2021; Accepted March 5, 2021.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: To confirm the effect of 0.15% sodium hyaluronate on tear film and ocular surface disorders after vitrectomy surgery.
Methods: The control group 19 patients and the test group 20 patients who underwent vitrectomy were enrolled. The control group took only antibiotics and steroids eye drops after surgery for 1 month, and the test group used 0.15% sodium hyaluronate eye drops for 2 months additionally. Ocular surface disease index (OSDI), tear film break-up time, Schirmer test, corneoconjunctival staining and meibomian gland seretion test were evaluated before surgery (baseline), 1 day, 1 week, 1 month, and 2 months after surgery.
Results: There was significant difference between the control and trial group at 1 week in Schirmer test (p = 0.038). In OSDI, the score significantly increased until 2 months after vitrectomy in the control group (p = 0.021). However, the test group recovered at 2 month after surgery. In control group, TBUT showed significant decrease at 1 month (p = 0.022) and Schirmer test showed significant decrease at 2 months (p = 0.048) compared to the baseline, but there was no difference in the test group. Corneoconjunctival staining showed early increase and then progressive decreasing tendency at postoperative period in both groups, but there was a significant decrease of corneal staining at 2 months (p = 0.007) compared to the baseline only in the test group.
Conclusions: Tear film and ocular surface disorders that occurred after vitrectomy worsen after surgery and then mostly recover. Postoperative 0.15% sodium hyaluronate instillation can alleviate the dry eye symptoms and is thought to contribute to early improvement of clinical findings.
Keywords : 0.15% sodium hyaluronate; Dry eye; Ocular surface; Vitectomy

March 2021, 20 (1)