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Incidence and Clinical Characteristics of Pediatric Thyroid Associated Ophthalmopathy in Korean
Ann Optom Contact Lens 2019;18:111-115
Published online December 25, 2019
© 2019 The Korean Optometry & Contact Lens Study Society

Sae Mi Lee, MD, Moon Kyeong Shin, MD, Nam Yeong Kim, MD, Hee Bae Ahn, MD, PhD

Department of Ophthalmology, Dong-A University College of Medicine, Busan, Korea
Correspondence to: Hee Bae Ahn, MD, PhD
Department of Ophthalmology, Dong-A University Hospital, #26 Daesingongwon-ro, Seo-gu, Busan 49201, Korea
Tel: 82-51-240-5227, Fax: 82-51-254-1987
Received September 17, 2019; Revised October 13, 2019; Accepted October 30, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: To investigate the incidence of pediatric thyroid associated ophthalmopathy (TAO) in Korean, compared diagnosed TAO group and non-diagnosed TAO group to evaluate clinical characteristics of pediatric TAO.
Methods: We retrospectively analyzed the medical records (ophthalmic examination, thyroid function test) 84 patients who visited ophthalmology outpatient clinic for evaluating TAO after diagnosed thyroid disease in pediatric department from July 2008 to July 2018. We compared thyroid function test diagnosed TAO group and non-diagnosed TAO group.
Results: Among 84 patients, 28 patients (33.3%) were diagnosed with TAO. None of the patients diagnosed with TAO had severe ophthalmic complication including diplopia, vision loss, visual field defect, decreasing color vision. Compared thyroid function test in two group (TAO vs. non-TAO), TSH (p = 0.07), free T4 (p = 0.07), and Tg-Ab (p = 0.3) did not show statistically significant differences in two groups. But TAO group showed high levels of TRAb and showed meaningful differences in statistically (p = 0.01).
Conclusions: The incidence rate of pediatric TAO in Korean was 33.3%. Require screening of TAO when diagnosing pediatric thyroid disease. TAO group showed high TRAb level compared with non-diagnosed TAO group. Children with high TRAb level needs attention and regular follow up.
Keywords : Child; Pediatrics; Thyroid assosicated opthalmopathy

December 2019, 18 (4)